Nano-bioglass: A Versatile Antidote for Bone Tissue Engineering Problems

Abstract

Bioactive-glass scaffolds are crucial in bone tissue engineering since they act as temporary templates for tissue regrowth, providing structural support to the cells. The enhancement of the angiogenic potential of implantable biomaterial scaffolds is receiving much attention in tissue engineering strategies. The angiogenic potential of most synthetic and natural materials used to fabricate tissue-engineered scaffolds is limited, insufficient, or even absent, numerous attempts have been made to enhance angiogenesis associated with tissue-engineered constructs, either by changing physicochemical properties or by supplementation with angiogenic factors. In order to improve the angiogenic effect of bioglass nano potash alum was incorporated to the Bioglass. Both Bioglass and alum doped Bioglass were synthesised by wet chemical method (sol-gel method) and its physiological properties were studied using TGA, XRD, FESEM, its cytocompatibility was studied by in vitro cell culture studies, and these bioglass are able to form a hydroxycarbonate apatite layer on their surface when in contact with an aqueous solution.