Abstract
AbstractOvercoming tumor resistance is one of the major challenges encountered in cancer treatment. With the rapid development of nanotechnology in recent years, nano‐assemblies have become promising candidates due to their strong potential to overcome the drug resistance of tumors. They have a high degree of adaptability, including size and composition regulation, surface versatility and the possibility of combining multiple therapeutic approaches through a single nanoparticle platform. Among multiple self‐assembled component materials, biomacromolecules have attracted ever growing attention because of their unique molecular structures, natural biocompatibility and multifunctional properties. Herein, various mechanisms of nano‐assembly utilization overcoming cancer drug resistance are first summarized, and then the roles and research progress of typical biomacromolecules (such as polysaccharides, proteins and nucleic acids) in nano‐assemblies capable of overcoming cancer drug resistance are described. Finally, the potential challenges and prospects of the clinical application of biomacromolecule‐based nano‐assemblies are analyzed and discussed. © 2021 Society of Industrial Chemistry.
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