Abstract
Recently, nanotechnology research studies have been proven that use of various nanoparticles as drug delivery systems to target and to annihilate pathogenic microorganisms may be a good solution for prevention and treatment of severe infection. In the last few years, antimicrobial drug encapsulation into nano-sized systems has materialized as a promising alternative that increased drug efficacy and minimized adverse effects. Physicochemical properties of erythromycin-loaded polymer nanoparticles were assessed using particle size distribution, HPLC, FTIR, TG/DTA, and SEM characterization techniques. The as-prepared samples exhibited an average particle size of 340 and 270 nm, respectively, with erythromycin content of 99.7% in both samples. From the release profile of erythromycin from PLA/PLGA, a prolonged drug release can be observed from both Ery-PLA and Ery-PLGA nanostructures. Morphology images exhibited spherical, rigid, and ring-shaped nanoparticles. Thermal analytical study in the case of Ery-PLA and Ery-PLGA samples showed that pure drug has an endothermic peak at around 150 °C assigned to a melting point. The antibiotic melting peak disappeared for both antibiotic-loaded PLA and PLGA nanoparticles thermographs, denoting the presence of erythromycin. This indicates that the antibiotic is uniformly dispensed throughout the host polymer matrix at nanometer scale. FTIR spectra of Ery-PLA and Ery-PLGA nano-architectures with almost similar peaks indicated no alteration in chemical structure of drug-loaded polymer nanoparticles.
Highlights
Bacterial infections happen when microorganisms exhibit its pathogenicity in‐
In the case of erythromycin‐loaded PLGA nanoparticles, approximately 55% of drug was released within 4 h, while 75% was released within 3 days
Our study was based on obtaining and characterizing antibiotic-loaded polymeric nanoparticles, assuming that the therapeutic efficacy of erythromycin would be greatly increased by loading the drug into biocompatible polymer-based nanoparticles compared to the free antibiotic
Summary
Bacterial infections happen when microorganisms exhibit its pathogenicity in‐. Introduction ducing disease and causing damage of the host area. This drug resistance caused by the excess and misuse of the antimicrobial agents, limiting issue determined multidisciplinary research to find improved therapies to defeat antibi‐ Their efficacy, represents a major interesttofor publicand health today. An important approach prevent to treat several infections caused multidisciplinary research to find improved therapies to defeat antibiotic resistance. By drug resisting pathogens is the use of drug‐loaded nanoparticles in order to deliver An the important approach prevent and to treat several infections caused by drug resisting antimicrobial agent totothe targeted area. Infections treatment, often prescribed as an alternative to penicillin allergic patients It is Erythromycin (Figure 1), a macrolide antibiotic, is currently used for several bacterial an effective drug administered as a prophylactic treatment or for various bacterial infec‐. This work focused on preparing erythromycin-loaded poly (lactic acid) (PLA) and poly (lactic-co-glycolic acid) (PLGA) and further evaluation of this broad spectrum curative agent encapsulated into polymer matrix
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