Abstract
In chloralose-anaesthetized cats the iontophoretic application of substance P produced an excitation of dorsal horn nociceptive units, as found in earlier studies. Naloxone (0.1–0.2 mg/kg, IV) failed to abolish this response to substance P in any of the 9 cats studied. In 4 additional cats nociceptive units were tested with morphine (1.0–3.2 mg/kg, IV) and substance P in case the antinociceptive effect of descending pathways is mediated via an excitatory action, but in each case morphine and substance P produced opposite effects (depression and excitation, respectively), suggesting that this was not the case. The present results fail to support a naloxone-antagonizable inhibitory effect of substance P in the spinal cord.
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