Abstract
Conditioned place preference (CPP) paradigm has proved to be a valuable tool in investigation of rewarding properties of drugs. In this method the subjects learn to associate the primary rewarding stimulus to the environmental stimulus, i.e. the environmental secondary stimulus acquires rewarding properties through the conditioning. The rewarding effects of morphine are though to be mediated by μ-opioid receptor, but the roles of subtypes of μ-receptor (μ1 and μ2) in this effect are still unclear. Also, the role of δ-opiod receptor in morphine reward has not been fully clarified
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