Abstract
The bacterial DNA synthesis inhibitor, nalidixic acid, inhibits DNA replication to different extents in various strains of E.coli, and the amount of inhibition is dependent on the growth temperature. DNA synthesis in the temperature-sensitive DNA replication mutant, dna F (a mutant with a defective ribonucleotide reductase), is sensitive to nalidixic acid at the permissive temperature, but is unusually resistant to nalidixic acid at the non-permissive temperature. This behavior is directly correlated with the dna F mutation, since it is not present in the parent strain of dna F, nor in a temperature-independent revertant of dna F. The results are discussed in terms of two modes of DNA replication, one sensitive to nalidixic acid and the other resistant to the drug.
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