Abstract
Nakijiquinones C ( 1) and D ( 2), new sesquiterpenoid quinones with a serine or a threonine residue, respectively, have been isolated from an Okinawan marine sponge of the family Spongiidae and the structures were determined by spectroscopic data and chemical correlations with a known compound, isospongiaquinone ( 5). Nakijiquinones and synthetic related compounds exhibited inhibitory activity against c-erbB-2 kinase.
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