Abstract
The aim of this study is to determine the usefulness of the low-price digital microscope in the identification of vascular changes in the nail bed of patients with systemic sclerosis and its relationship with autoantibodies involved.
Highlights
Nailfold capillaroscopy (NFC) is a non-invasive and useful tool that permits Rheumatologists to evaluate microvascular abnormalities found in Raynaud’s Phenomenon (RP) frequently associated to systemic connective tissue diseases (SCTD) in particular patients with systemic sclerosis (SSc) [1,2,3]
Anti Scl-70 was positive in 10% of the patients with scleroderma pattern, 12.5% with active stage and 0% with late stage
NFC by digital microscope is useful to determine the different patterns that can be observed in systemic sclerosis with a good quality
Summary
Nailfold capillaroscopy (NFC) is a non-invasive and useful tool that permits Rheumatologists to evaluate microvascular abnormalities found in Raynaud’s Phenomenon (RP) frequently associated to systemic connective tissue diseases (SCTD) in particular patients with systemic sclerosis (SSc) [1,2,3]. NFC allows us to distinguish between primary (idiopathic) to secondary (disease associated) RP and classify the microvascular abnormalities as “early”, “active” and “late” in scleroderma pattern or nonscleroderma pattern which is divided into normal and non-specific [8,9]. There are specific antibodies that are related to manifestations and complications of the disease such as anti-centromere antibody (ACA) that predict subcutaneous calcinosis, pulmonary arterial hypertension (PAH), and gastrointestinal involvement, antibodies against DNA topoisomerase I (ATA) known as anti Scl-70 that can predict the development of interstitial lung disease (ILD) and digital ulcers but appear to be protective against PAH [12,13,14]
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