Abstract
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T gene polymorphisms have been reported to influence the risk for digestive tract cancer (DTC) in many studies; however, the results remain controversial and ambiguous. We therefore carried out a meta-analysis of published case-control studies to derive a more precise estimation of any associations. Electronic searches were conducted on links between this variant and DTC in several databases through April 2012. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of associations in fixed or random effect models. Heterogeneity and publication bias were also assessed. A total of 21 case-control studies were identified, including 6,198 cases and 7,583 controls. Overall, there was a statistically significant association between the NQO1 C609T polymorphism and DTC risk (TT vs. CC: OR=1.224, 95%CI=1.055-1.421; TT/CT vs. CC: OR=1.195, 95%CI=1.073-1.330; TT vs. CT/CC: OR=1.183, 95%CI=1.029-1.359; T vs. C: OR=1.180, 95%CI=1.080-1.290). When stratified for tumor location, the results based on all studies showed the variant allele 609T might have a significantly increased risk of upper digest tract cancer (UGIC), but not colorectal cancer. In the subgroup analysis by ethnicity, we observed a significantly risk for DTC in Caucasians. For esophageal and gastric cancer, a significantly risk was found in both populations, and for colorectal, a weak risk was observed in Caucasians, but not Asians. This meta-analysis suggested that the NQO1 C609T polymorphism may increase the risk of DTC, especially in the upper gastric tract.
Highlights
Digestive tract cancers are the most common malignant tumors worldwide, with three million new cases each year (Parkin et al, 2005; Kanavos, 2006), of which Esophageal carcinoma is the sixth leading cause of cancer death in the world (Enzinger et al, 2003), Gastric cancer is the fourth commonest cancer and the second commonest cause of cancer death, globally (Ferlay et al, 2008), colorectal cancer is the third most common cancer in males and the second in females (Jemal et al, 2011)
NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T gene polymorphism and gastric cancer: Totally, five studies including 698 cases and 1,263 controls examined the effect of NQO1 C609T gene polymorphism on gastric cancer
A single nucleotide polymorphism(CgT) at position 609 of the NQO1 cDNA has been associated with susceptibility to tumors induced by chemical carcinogens
Summary
Digestive tract cancers are the most common malignant tumors worldwide, with three million new cases each year (Parkin et al, 2005; Kanavos, 2006), of which Esophageal carcinoma is the sixth leading cause of cancer death in the world (Enzinger et al, 2003), Gastric cancer is the fourth commonest cancer and the second commonest cause of cancer death, globally (Ferlay et al, 2008), colorectal cancer is the third most common cancer in males and the second in females (Jemal et al, 2011). The carcinogenesis of DTC is a complex, multifactorial, and multistep event, in which many factors are implicated, such as genetic factors, cigarette smoking, heavy alcohol drinking, and poor dietary pattern (Compare et al, 2010). Except for these shared risk factors, different primary sites of DTC cancers have different risk factors and different etiologies. Genetic factors are increasingly recognized as major contributors to DTC, including single nucleotide polymorphisms (SNPs) (Chen et al, 2010). We performed this meta-analysis to get a more precise estimation of the association
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