Abstract
The hormone-responsive external plasma membrane NADH oxidase (NOX) was first described for right side-out vesicles of plasma membranes isolated from dark-grown seedlings of soybean (Morre et al., 1986) in response to the auxin regulator of plant growth, 2,4-dichlorophenoxyacetic acid (2,4-D). A comparable hormone- and growth factor responsive NADH oxidase was subsequently described for isolated plasma membranes of rat liver. When hepatoma plasma membranes were examined, an NADH oxidase activity was observed but the activity was constitutively activated and no longer growth factor responsive (Bruno et al., 1992). Subsequent work has focused largely on the growth factor-insensitive activity of transformed cells grown in culture (Morre et al., 1995a). The latter has now been extensively characterized and is distinguished from that of non-transformed cells and tissues by being inhibited by both thiol reagents and several antitumor or potential antitumor drugs.
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