Abstract
The uptake of taurocholate in rat small intestine was investigated with everted sacs and epithelial cells. It was ascertained by means of these assay systems that Na+-dependent taurocholate transport would be confined to the distal ileum. The effect of fasting on the Na+-dependent taurocholate transport was assessed using isolated epithelial cells from there. Fasting for 2 days led to a considerable decrease in the taurocholate uptake by the epithelial cells regardless of Na+ -dependent or -independent transport. When kinetic parameters (Kt, Vmax) were obtained for net Na+-dependent taurocholate transport from double-reciprocal plots of the taurocholate concentration against its corresponding transport rate, these values suggested that a diminution not in the affinity for taurocholate but in the quantity of “carrier” protein would have arisen from semi-starvation.
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