Abstract
Summary: Mutants, designated gdhA, deficient in NADP-glutamate dehydrogenase activity grow poorly using inorganic nitrogen but normally using amino acids as nitrogen sources. The gdhA mutants are not repressed by ammonia for a number of enzyme and uptake systems. The nine gdhA mutations are allelic and located in linkage group III; gdhAi is recessive in the heterozygous diploid with respect to both NADP glutamate dehydrogenase activity and ammonium regulation. Mutants, designated gdhB, deficient in NAD-glutamate dehydrogenase activity are unable to utilize l-glutamate as a carbon source, but can utilize inorganic and organic nitrogen as nitrogen sources. The four gdhB mutations are allelic, located in linkage group IV, and gdhBI is recessive in the heterozygous diploid. The gdhB mutants are repressed for the ammonium regulated systems which are not repressed in gdhA mutants.
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