Abstract
The first reports of cardiac Na/K-ATPase signaling, published 20 years ago, have opened several major fields of investigations into the cardioprotective action of low/subinotropic concentrations of cardiotonic steroids (CTS). This review focuses on the protective cardiac Na/K-ATPase-mediated signaling triggered by low concentrations of ouabain and other CTS, in the context of the enduring debate over the use of CTS in the ischemic heart. Indeed, as basic and clinical research continues to support effectiveness and feasibility of conditioning interventions against ischemia/reperfusion injury in acute myocardial infarction (AMI), the mechanistic information available to date suggests that unique features of CTS-based conditioning could be highly suitable, alone /or as a combinatory approach.
Highlights
The prompt restoration of blood flow to reinstate the perfusion of the ischemic myocardium has substantially improved the outcomes for patients hospitalized with acute myocardial infarction (AMI) [1]
As basic and clinical research continues to support the effectiveness and feasibility of conditioning interventions, this review covers insights into the protective cardiac Na/K-ATPase-mediated signaling triggered by ouabain and other cardiotonic steroids (CTS), as well as its potential application in the context of the enduring debate over the use of CTS in the ischemic heart
In Pierre et al [37], transient exposure to a subinotropic concentration of ouabain and wash-out prior to ischemia/reperfusion induced a structural and functional protection comparable to that observed with ischemic preconditioning (IPC) in this model
Summary
The prompt restoration of blood flow to reinstate the perfusion of the ischemic myocardium has substantially improved the outcomes for patients hospitalized with acute myocardial infarction (AMI) [1]. As basic and clinical research continues to support the effectiveness and feasibility of conditioning interventions, this review covers insights into the protective cardiac Na/K-ATPase-mediated signaling triggered by ouabain and other cardiotonic steroids (CTS), as well as its potential application in the context of the enduring debate over the use of CTS in the ischemic heart.
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