Abstract
The importance of HCO3 − transport in the colonic epithelium is underscored by the multitude of vital functions it has been associated with, including mucosal protection via HCO3 − secretion and intracellular pH (pHi) regulation, Cl− secretion, NaCl absorption, absorption of short-chain fatty acids (SCFAs) as the primary nutrient for the colonocyte, and possibly also mucin unfolding [1]. HCO3 − can leave the cell via apical conductance, Cl−/HCO3 − exchange, or in exchange for SCFAs [2]. Prerequisite for the intracellular presence of HCO3 − are its intracellular generation catalyzed by carbonic anhydrases and/or its uptake across the basolateral membrane, where Na+/H+ exchange (NHE) and Na+/HCO3 − cotransport (NBC) are functional [3,4].
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