Na-diclofenac β -cyclodextrin inclusion complex on cotton wound dressing

Abstract

This paper deals with the production of a wound dressing capable of releasing sodium diclofenac as a drug for curing inflammations. Sodium diclofenac was used as an inclusion compound with β -cyclodextrin and then attached to the cotton wound dressing by a cross-linking agent, namely, dimethyl dihydroxyl ethylene urea (DMDHEU). Here some analyses were performed such as UV spectrophotometry and HNMR spectroscopy to ensure the complex formation of β -cyclodextrin and sodium diclofenac, surface morphology studies by SEM, and dissolution studies for drug release. The results revealed that increasing the amount of complex increases the drug contained in the wound dressing and the cross-linking agent prolongs the drug release time. Also, the existence of ethanol as a solvent for sodium diclofenac increases the drug released during the initial hours of drug release tests.