Abstract
Major facilitator superfamily domain containing 2A (MFSD2A) is a membrane protein that is highly enriched within endothelial cells of the blood-brain and blood-retinal barriers where it mediates Na+-dependent uptake of the ω-3 fatty acid docosahexaenoic acid (DHA) in the form of lysophosphatidylcholine (LPC-DHA) into the brain and eyes, respectively. MFSD2A shares the 12 transmembrane domain architecture with other MFS family members. However, the molecular details of the transport process remain unknown, because unlike most MFS proteins, MFSD2A transports lysolipids rather than water-soluble molecules, suggesting that molecular mechanism of MFSD2A-mediated transport can be different and more akin to that of flippases.
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