Abstract
N6-methyladenine: a potential epigenetic mark in eukaryotes.
Highlights
Methylation modifications in DNA in the forms of 5-methylcytosine (5mC) and N6-methyladenine (6mA) are one of the most important epigenetic marks that have been proposed to regulate gene expression and control numerous cellular and biological processes
In Drosophila, we found that 6mA was highly present at the very early embryonic stage, but very low levels were present at the late embryonic stage, suggesting that 6mA modification may be dynamic during embryogenesis
Further evidence revealed that the dynamics of 6mA modification were tightly regulated by a DNA 6mA demethylase (DMAD), the Drosophila Tet-like protein
Summary
Methylation modifications in DNA in the forms of 5-methylcytosine (5mC) and N6-methyladenine (6mA) are one of the most important epigenetic marks that have been proposed to regulate gene expression and control numerous cellular and biological processes. Previous studies have reported that 6mA is present at considerable levels in genomic DNA from a number of unicellular eukaryotes, and is detected in some plant DNA. 6mA has been shown to be present at extremely low levels in most higher eukaryotes and in mammals.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
