Abstract
N-[4-(1-Methyl-1H-imidazol-2-yl)-2,4′-bipyridin-2′-yl]benzene-1,4-diamine was synthesized with a good yield by the reaction of 2′-chloro-4-(1-methyl-1H-imidazol-2-yl)-2,4′-bipyridine with 4-phenylenediamine. The functionalization of the pyridine was accomplished by a nucleophilic aromatic substitution (SNAr) reaction that afforded the target compound. The synthesized compound was characterized by chemical analysis, which includes nuclear magnetic resonance (NMR) (1H-NMR and 13C-NMR), Thin Layer Chromatography-Mass Spectrometry (TLC-MS), high- performance liquid chromatography (HPLC), Gas Chromatography-Mass Spectrometry (GC-MS), and elemental analysis.
Highlights
Imidazoles are an important and essential class of heterocyclic compounds and include many substances of both biological and chemical interest
In continuation of previous studies [8–19], a new imidazole–bipyridine derivative was synthesized for the first time, accomplished by a nucleophilic aromatic substitution (SNAr) reaction (Scheme 1)
The desired compound was compound was characterized by chemical analysis methods, which include nuclear magnetic characterized by chemical analysis methods, which include nuclear magnetic resonance (NMR), resonance (NMR), Liquid chromatography-mass spectrometry (LC-MS), high-performance liquid
Summary
Imidazoles are an important and essential class of heterocyclic compounds and include many substances of both biological and chemical interest. -yl]benzene-1,4-diamine was achieved named N-[4-(1-methyl-1H-imidazol-2-yl)-2,4′-bipyridin-2′-yl]benzene-1,4-diamine was achieved in in this paper with a good yield, based on a nucleophilic aromatic substitution reaction of this paper with a good yield, based on a nucleophilic aromatic substitution reaction of 2′-chloro-4-(10 -chloro-4-(1-methyl-1H-imidazol-2-yl)-2,40 -bipyridine with 4-phenylenediamine. The desired compound was compound was characterized by chemical analysis methods, which include nuclear magnetic characterized by chemical analysis methods, which include nuclear magnetic resonance (NMR), resonance (NMR), Liquid chromatography-mass spectrometry (LC-MS), high-performance liquid Liquid chromatography-mass spectrometry (LC-MS), high-performance liquid chromatography chromatography (HPLC), Gas
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