N-3 Polyunsaturated Fatty Acids of Marine Origin and Multifocality in Human Breast Cancer.

Lobna Ouldamer,Gilles Body,Stephan Chevalier,Caroline Goupille,Philippe Bougnoux,Jean Philippe Cottier,Flavie Arbion,Anne Vildé,Hervé Guillou

doi:10.1371/journal.pone.0147148

Abstract

ObjectiveThe microenvironment of breast epithelial tissue may contribute to the clinical expression of breast cancer. Breast epithelial tissue, whether healthy or tumoral, is directly in contact with fat cells, which in turn could influence tumor multifocality. In this pilot study we investigated whether the fatty acid composition of breast adipose tissue differed according to breast cancer focality.MethodsTwenty-three consecutive women presenting with non-metastatic breast cancer underwent breast-imaging procedures including Magnetic Resonance Imaging prior to treatment. Breast adipose tissue specimens were collected during breast surgery. We established a biochemical profile of adipose tissue fatty acids by gas chromatography. We assessed whether there were differences according to breast cancer focality.ResultsWe found that decreased levels in breast adipose tissue of docosahexaenoic and eicosapentaenoic acids, the two main polyunsaturated n-3 fatty acids of marine origin, were associated with multifocality.DiscussionThese differences in lipid content may contribute to mechanisms through which peritumoral adipose tissue fuels breast cancer multifocality.

Highlights

Epithelial breast tissue tumorigenesis may arise from a single or from several distinct sites within the same breast, leading to multifocality, defined as multiple simultaneous ipsilateral and synchronous breast carcinomas [1]
We found that decreased levels in breast adipose tissue of docosahexaenoic and eicosapentaenoic acids, the two main polyunsaturated n-3 fatty acids of marine origin, were associated with multifocality
These differences in lipid content may contribute to mechanisms through which peritumoral adipose tissue fuels breast cancer multifocality

Summary

Introduction

Epithelial breast tissue tumorigenesis may arise from a single or from several distinct sites within the same breast, leading to multifocality, defined as multiple simultaneous ipsilateral and synchronous breast carcinomas [1]. We found that decreased levels in breast adipose tissue of docosahexaenoic and eicosapentaenoic acids, the two main polyunsaturated n-3 fatty acids of marine origin, were associated with multifocality. These differences in lipid content may contribute to mechanisms through which peritumoral adipose tissue fuels breast cancer multifocality.

Results

Conclusion