Abstract
Quinolinyl amines are important organic compounds which possess a variety of pharmacological activities such as antimalarial, antifungal, hypotensive and antidepressant activity.
Highlights
Quinolinyl amines are important organic compounds which possess a variety of pharmacological activities such as antimalarial, antifungal, hypotensive and antidepressant activity [1,2,3,4]
From the various conditions adopted for the synthesis of secondary amines reported in the literature, synthesis via nucleophilic substitution is still an important method [5]
The solvent was removed under reduced pressure and the residue was dissolved in ether, washed with sodium bicarbonate solution (10%, 25 mL) and twice with water (25 mL), dried over sodium sulphate and concentrated in vacuo to give a residue which was crystallized from methanol
Summary
Quinolinyl amines are important organic compounds which possess a variety of pharmacological activities such as antimalarial, antifungal, hypotensive and antidepressant activity [1,2,3,4]. From the various conditions adopted for the synthesis of secondary amines reported in the literature, synthesis via nucleophilic substitution is still an important method [5]. As a part of our research programme on quinoline derivatives [6], we report the synthesis of N-[(2-chloro-6-methylquinolin3-yl)methyl]aniline (Figure 1) by nucleophilic substitution of 2-chloro-3-(chloromethyl)-6methylquinoline with aniline in absolute ethanol in the presence of triethylamine (TEA) as base
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