N22 Compliance with Anti-TNF Alpha Treatment and Quality of Life of Inflammatory Bowel Patients: A Descriptive and Correlational Study

Abstract

Abstract Background Today, anti-TNF agents are often preferred in the treatment of inflammatory bowel diseases. During this long-term treatment, patients' compliance with the treatment is very important. This study aims to determine the relationship between compliance with anti-TNF alpha treatment and quality of life in inflammatory bowel patients. Methods This study is currently being carried out at Gazi Hospital Gastroenterology Department, Inflammatory Bowel Diseases Outpatient Clinic. The study will be carried out between November and February 2024. Data are collected using the "Patient Information Form", "Inflammatory Bowel Diseases Quality of Life Scale", "Anti-TNF Alpha Treatment Compliance Scale". Whether the variables were suitable for normal distribution was determined by the Kolmogorov-Smirnov test. Since parametric test assumptions were not met, Mann-Whitney U test, Kruskal Wallis test and Sperman correlation analysis were used in the analysis of scale scores. Statistical significance value was accepted as p<0.05. Results In this section, the pilot results of the study are presented and its implementation is ongoing (Number of patients reached: 117). The mean age of the patients participating in the study was determined to be 38.99±13.73 (minimum=18, maximum=68). It was determined that 53.7% of the patients were male, 57.3% were married and 42.7 of them had no children. The diagnosis of 65% of patients is Crohn's disease. The rate of patients being diagnosed with inflammatory bowel disease for 3-5 years was found to be 29.9%. The total score of the Inflammatory Bowel Diseases Quality of Life Scale was found to be 160.04±32.24 (minimum=88.00, maximum=224.00). The total score of the Anti-TNF Alpha Treatment Compliance Scale was found to be 2.36±0.72 (minimum=1.00, maximum=4.58). It was determined that there was a strong negative relationship between the total scores of the scales (p= <0.001). Conclusion It can be said that the treatment compliance of the patients is at a moderate level and their quality of life is at a good level. The relationship between patients' treatment compliance and their quality of life is also negative.