Abstract
Objective: To assess the effects of serum and follicular fluid total oxidant (TOC) levels, total antioxidant capacity (TAC), and oxidative stress index (OSI) on oocyte maturation, fertilization, embryogenesis, and clinical pregnancy outcomes in In Vitro Fertilization (IVF) cycles of infertile patients.Materials and Methods: One hundred patients having infertility and underwent ART enrolled the study group and blood samples were collected on gonadotropin starting, oocyte pick-up (OPU) and embryo transfer (ET) days. Additionally, follicular fluid specimen obtained during OPU was collected. TOC, TAC levels and OSI in serum samples and follicular fluid specimens between clinically pregnant and non-pregnant patients were compared.Results: No significant difference was noted between clinically pregnant and nonpregnant patients in terms of the woman's age, duration of infertility, ovarian reserve or number of transferred embryos. There was also no significant difference in TAC, TOC and OSI levels in serum samples obtained during three phases of treatment cycle (basal gonadotropin starting day, OPU day and ET day) and in follicular fluid samples. Conclusion: TAC, TOC and OSI seem to be ineffective to predict clinical pregnancy as an outcome in patients who underwent ART.
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