N, O-Diacyl-4-benzoyl- N-phenylhydroxylamines as photoinduced DNA cleaving agents

Abstract

Photoinduced homolytic fission of nitrogen–oxygen bond in N, O-diacyl-4-benzoyl- N-phenylhydroxylamines using ⩾310 nm UV light for 10 min produced acylaminyl and acyloxy radicals, which resulted in single strand cleavage of DNA at pH 7.0. Further the DNA cleaving ability of N, O-diacyl-4-benzoyl- N-phenylhydroxylamines found to depend both on its concentration and acyl substituents.