Abstract
AbstractNitrogen‐centered radicals are versatile synthetic intermediates with the ability to undergo diverse reactions. However, the utility of these reactive species in NN coupling reactions, especially in nitrogen‐rich heterocycles, remains a significant challenge due to the high electronegativity of the nitrogen atoms and the poor molecular stability of high‐nitrogen compounds. In this work, the possibility of NH bond cleavage in different functionalized pyrazoles to produce corresponding nitrogen‐centered radicals was investigated through density functional theory calculations. Based on the calculated results, the NN bridged 4c and 4e were synthesized with expected reaction efficiencies, which were further analyzed by frontier molecular orbital theory. Furthermore, the molecular stability of the synthesized NN bridged bipyrazoles was also studied.
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