N,N′-Bis[(R)-2-hydroxy-2-phenylethyl]-N,N′-bis[(S)-1-phenylethyl]pyridine-2,6-dicarboxamide: stabilization of an asymmetric conformer through the formation of a double intramolecular hydrogen bond

Abstract

The title compound, C39H39N3O4, although having potential C2 molecular symmetry, crystallizes as an asymmetric conformer, due to a couple of strong intramolecular hydrogen bonds involving hydroxyl groups and a pyridine N atom. This geometrical feature explains why this compound behaves as a poor chiral inductor for asymmetric synthesis.