N, N′-Bis[4-( N-alkylamidino)phenyl]homopiperazines as anti- Pneumocystis carinii agents

Tien L Huang,Bin Tao,Yvonne Quarshie,Sherry F Queener,Isaac O Donkor

doi:10.1016/s0960-894x(01)00541-8

N, N′-Bis[4-( N-alkylamidino)phenyl]homopiperazines as anti- Pneumocystis carinii agents

Tien L Huang, Bin Tao + Show 3 more

https://doi.org/10.1016/s0960-894x(01)00541-8

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Journal: Bioorganic & Medicinal Chemistry Letters	Publication Date: Aug 23, 2001
Citations: 18

Affiliation: Indiana University – Purdue University Indianapolis, Xavier University of Louisiana, University of Tennessee at Knoxville

#Pneumocystis Carinii #Cell Culture Model + Show 8 more

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Abstract

The synthesis, anti- Pneumocystis carinii activity and DNA binding properties of eight new N, N′-bis[4-( N-alkylamidino)phenyl]homopiperazines are reported. Compounds 2 and 8 were the most potent and caused about 70% inhibition of Pneumocystis carinii growth in a cell culture model at 1 μM concentrations.

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