Abstract
We have used a morphological approach to evaluate the role of NMDA receptors (NMDAR) in postnatal development of brainstem neurons in awake rats. Chronic NMDAR blockade was performed by placing drug-impregnated Elvax implants over the brainstem at the fifth postnatal day (P5). Compared with control, NMDAR blockade led to a transient increase in dendritic arbor area and filopodium density until P12 followed by a rapid decline in both parameters. Electron microscopy observations showed that these changes correlated with an increase in synapse density at P14 followed by a decrease in synapse density at P28 if chronic NMDAR blockade was maintained until P21. These results support the hypothesis that synapse formation does not require NMDAR activation. In addition, our data suggest a dual role for NMDAR in controlling the synapse number. Early in development NMDARs may be involved in controlling the rate of synapse elimination. Later on, they may subserve synapse stabilization. The physiological significance of these results is discussed.
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