Abstract
The p- and o-substitution of the benzene ring of poly(β-benzyl- l-aspartate) (PBLA) with a nitro group induces a reversal of the helix sense in the PBLA. Therefore, two series of random copolymers of benzyl- l-aspartate with o- and p-nitrobenzyl- l -aspartate were prepared in order to study the left-handed→right-handed α-helix transition. The conformational behaviour has been studied by nuclear magnetic resonance spectroscopy and the left-handed→right-handed α-helix transition has been observed from the α-C H shift, from CDCl 3 solutions. Moreover, for each copolymer, the α-helix→coil transition was also studied in CDCl 3 trifluoroacetic acid mixtures. In this case, the transition can be observed from the α-C H shift and from the splitting of the β-C H 2 resonance in the α-helical form also.
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