Abstract
The importance of the polymorphism of DNA in the reaction with the chemical carcinogen N-hydroxyaminofluorene is studied by means of a supercoiled plasmid containing an insert of (dC-dG) 16. Immunochemical titration and the determination of the binding spectrum of aminofluorene adducts show that the carcinogen reacts with B-DNA but not with Z-DNA and that conformational changes of the B-DNA- Z-DNA junctions occur as a function of the superhelical density.
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