Abstract
Pyridine and 4-substituted pyrimidine derivatives incorporating a sulphur functional side-group were evaluated as potential radioprotective agents by screening tests in mice. 2-(2-Pyridyl)ethanethiol and its derivatives showed some radioprotective action when administered intraperitoneally, but all were inferior to 2-pyridinemethanethiol. They showed no protection when administered orally. Substitution of the pyridine ring by chlorine gave compounds which also showed inferior radioprotective properties to those demonstrated by 2-pyridinemethanethiol. Corresponding phosphorothioates also exhibited little activity. The pyrimidine derivatives showed protection of a low order.
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