Abstract
An N -heterocyclic carbene (NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N- sulfonyl imines is developed for access to linear β -aminoenone products. The β -aminoenones containing cyclopropyl fragments can be afforded in moderate to excellent yields under mild conditions. The reaction features excellent trans -diastereoselectivities and the desired aminoenone products are all afforded as Z -isomers. An N -heterocyclic carbene (NHC)-catalyzed carbonyl nucleophilic substitution reaction between 1-cyclopropylcarbaldehydes and N -sulfonyl imines is developed for access to linear β -aminoenone products. The β -aminoenones containing cyclopropyl fragments can be afforded in moderate to excellent yields under mild conditions. The reaction features excellent trans -diastereoselectivities and the desired aminoenone products are all afforded as Z -isomers.
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