Abstract
Abstract: The formyl-peptides for-Glu-Leu-Phe-OMe 1 and for-Asp-Leu-Phe-OMe 2 were synthesized in order to study the influence of a net negative charge, along the side chain of the first residue, on human neutrophil biological responses. The compounds exert a weak chemotactic as well as secretory activity. Moreover, they are neither able to enhance intracellular calcium levels nor to elicit oxygen-dependent mechanisms.We suggest that the receptor pocket does not accept a net negative charge on the side chain of the first residue.
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