Abstract
A wide range of N-CF3 imidoyl chlorides were synthesized for the first time via the N-trifluoromethylation of nitriles in DCM by using AlCl3-activated PhICF3Cl as the CF3 source. The reactions of them with N-/O-/S-nucleophiles, as well as with 1,3-dipoles, were carried out to efficiently deliver N-CF3 amidines/imidates/thioimidates and N-CF3 azoles, demonstrating that they are a class of scalable NCF3-containing synthons in the synthesis of N-CF3 compounds.
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