N-Butylpyridoquinoxaline 1, 4-dioxide alleviates experimentally induced leukemia with up-regulating sphingosine-1-phosphate receptors

Mai M Kabeel ,Ahmed Ghoneim

doi:10.7324/japs.2019.90402

Abstract

Synthesis of Methyl 2-Cinnamamido-3-Hydroxy Propanoate Having Activity against P388 Leukemia CellsTeni Ernawati, Yulia Anita, Puspa Dewi Lotulung and Muhammad Hanafi

Highlights

Leukemia is a malignant transformation of hematopoietic cells which produces an abnormal leukemic clone of cells suppressing the production of normal blood cellular components (Duhrsen and Hossfeld, 1996)
This study aimed to investigate whether N-Butylpyridoquinoxaline 1, 4-Dioxide (NBPQD) has anti-leukemic effects
After applying NBPQD on the leukemic (DMBA-treated) rats, no significant change (p = 0.985) in the total white blood cell (WBC) number was noticed between the leukemic “NBPQD after dimethyl benza[a]anthracene (DMBA)” subgroup and the “carrier” group, revealing recovery of the normal total WBC number in the NBPQD-treated rats (Fig. 2)

Summary

Introduction

Leukemia is a malignant transformation of hematopoietic cells which produces an abnormal leukemic clone of cells suppressing the production of normal blood cellular components (Duhrsen and Hossfeld, 1996). Leukemia is one of the most predominant types of cancer, especially in children (Siegel et al, 2018). Being accounting for 2.5% of all cancers (Forman et al, 2003), leukemia was ranked 11th among the commonly diagnosed types of cancer (Todd et al, 2017). According to Siegel et al (2018), around 60,300 new cases of leukemia were expected to be diagnosed in the US in 2018. Based on cell type and rate of growth, leukemia is classified into four main groups: acute lymphocytic, acute myeloid, chronic. Causes of leukemia are diverse and they could be familial, infectious, physical, or chemical depending on the cell type and the individual variations from one patient to another (Pui, 1995). Obesity, smoking, and exposure to electromagnetic fields and ionizing radiation have been reported to be risk factors for the development of leukemia

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