Abstract
An unprecedent improvement in the reaction rate (from hours to minutes) was observed during the In-mediated allylation of isatins with allyl bromide in the presence of N-Boc-glycine. The observed phenomena were generalized as a general protocol for the allylation of differently substituted isatins with excellent yields in a short time and with a wide range of functional group tolerance. Evidence suggests the unique role of the N-Boc-glycine additive was to increase the rate of formation and increase the nucleophilicity of the allylindium organometallic reagent.
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