N-Benzoyl-N'-phenyl-2, 6-diaminobenzoic acid (F-1) の薬理学的研究(第二報)

Abstract

In a previous paper, it was reported that F-1, a new non-steroidal compound, had a potent inhibitory effect similar to that of fiufenamic acid (FA) and phenylbutazone (PB) on experimental acute inflammation. General pharmacological actions of F-1 are described herein. Analgesic action of F-1 was similar to that of mefenamic acid (MA) and more potent than that of FA and PB. F-1 did not show significant activities in such tests as locomotion, rotarod, anticonvulsion, hypnotic potentiation to barbiturates, hypothermic and anti-pyretic action. It appeared, therefore, not to have side effects on the central nervous system. It was also free of any effect on the cardiovascular and respiratory systems, renal function, blood coagulation and blood sugar level in doses causing anti-inflammatory effect. F-1 inhibited isolated intestinal movement and relaxed smooth muscle in a high concentration and did not show specific antagonistic action on such spasmogens as histamine, acetylcholine and BaCl2. F-1 inhibited contraction of the intestine by 5-HT and diarrhea by 5-HTP. Therefore, F-1 was found to have weak anti-serotonic action. F-1 was found to have potent anti-inflammatory action and few side effects. It may be considered that F-1 can be classified as a non-steroidal analgesic and anti-inflammatory agent.