Abstract
The acylation reaction of secondary (R 1 = H) β-enamino ketones [RCOCH=CHNR 1 R 2 , where R = CF 3 , CCl 3 , Ph, 4-FC 6 H 4 , 4-NO 2 C 6 H 4 , thien-2-yl; R 1 = H, Me; R 2 = Me, Bn, Ph, 4-NO 2 C 6 H 4 ] with trifluoroacetic anhydride or ethyl oxalyl chloride in pyridine led regiospecifically to a series of 14 N-acylated enaminones in good yields (72-88%). On the other hand, when tertiary enaminones (R 1 , R 2 = Me) were used, the acylation reaction led to a series of 12 C-acylated enaminones in good to excellent yields (75-92%).
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