Abstract
16 Quorum sensing (QS) is a mechanism that plays important roles in gene expression in response to an 17 expanding bacterial population. In many Gram-negative bacteria, N-acyl homoserine lactone is mainly 18 secreted as the diffusible signalling molecules. This QS system has been shown to control diverse array 19 of virulence and secondary metabolism. Recently, whole genome sequencing of Aeromonas veronii 20 biovar sobria strain 159 was performed. Genome comparison with closely-related Aeromonas species 21 showed that A. veronii strain 159 shares a high degree of genome synteny with A. hydrophila ATCC 22 7966. A detailed genome analysis and gene annotation led us to the findings that A. veronii strain 159 23 harbors QS system which relies on its signal generator, AveI and the transcriptional regulator, AveR. 24 This Aeromonas strain was found to secrete N-butanoylacyl homoserine lactone (C4-HSL). Its LuxIR 25 homologs are similar to proteins of LuxIR famililies among Aeromonas species. This study aims to 26 gain further insights into AveIR system and to compare with AhyIR from A. hydrophila ATCC 7966 27 and AsaIR from A. salmonicida. 28 29 30 31
Highlights
Quorum sensing (QS) is the term which refers to bacterial cell-cell communication to coordinate a diverse array of physiological behaviors in the entire communities
The acylhomoserine lactones (AHLs) prrofile of strain 159 was obtained by High Resolution Tandem Triple Quadrupole Mass Spectrometry (LC-MS/MS) System according to previously reported method (Wong et al, 2012)
The genome sequence has been deposited at DDBJ/EMBL/GenBank under the accession no
Summary
Quorum sensing (QS) is the term which refers to bacterial cell-cell communication to coordinate a diverse array of physiological behaviors in the entire communities. The basic mechanisms of AHL synthesis and regulation are found to be conserved in many species of proteobacteria despite expression of different target phenotypes (Miller and Bassler, 2001; Dong et al, 2002). Whole genome sequencing of this bacterium was performed and it was found that this strain shares a high degree of genome synteny with A. hydrophila ATCC 7966.
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