N-acetyltransferase activity as a possible criterion in prognosing the anti-tumor effect of cyclophosphamide.

Abstract

The results obtained in the present study indicated that a reduction in the activity of N-acetyltransferase (EC 2.3.1.5) occurs in cyclophosphamide-treated mice with sarcoma 37. A difference in variations of the level of N-acetyltransferase activity in outbred mice with and without tumors was observed in cyclophosphamide-treated animals. It was established that the effect of cyclophosphamide on the activity of N-acetyltransferase depends on the initial level of the enzyme activity (phenotype of acetylation) as well as on the genotype which determines the N-acetyltransferase activity.