Abstract
The appearance of the amino acid α-N-acetyl-L-histidine in embryos of the killifish, Fundulus heteroclitus a salt water fish and the zebrafish Brachydanio rerio , a freshwater fish have been investigated. In both species, appearance of NAcH parallels the appearance of acetylcholinesterase activity which occurs just prior to the establishment of the CNS-somatic reflex arc. In the killifish, there is a sharp rise in NAcH concentration just a few days before hatching which is not observed in the zebrafish. In both species, the NAcH content continues to rise for several days after hatching. A single treatment with Malathion, a potent AChE inhibitor has been found to decrease the content of NAcH in these embryos from 6–55% of control levels.
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