N-Acetyl Cysteine Loaded-Niosomes as a Mucolytic Agent for Acute Diseases and Respiratory Disorders

Abstract

Today, there is a strong interest in the development of new drug delivery systems using an inactive carrier for pharmaceutics. In recent years, several drug delivery systems have been introduced, such as liposomes, niosomes, transfersomes, and pharmacosomes. N-acetylcysteine, as a mucolytic agent, is prescribed for acute diseases and respiratory disorders, flu, colds, and bronchitis to reduce mucus viscosity. In this study, niosomes n-acetyl cysteine was prepared with a hydration thin film layer method. Niosome formation was confirmed by light and electron microscope images. To determine the average size of niosomes, zeta seizer instruments were used. To evaluate the effects of the medicine on niosomes membrane composition, Fourier transforms infrared spectra were obtained. The best formulation for this study was the Span 60 formula with a 70:30 ratio. An increase in drug concentration was accompanied by a similar rise in niosome capacity. The average size of niosome with different formulations was listed. The release time of the drug was obtained. The FTIR spectroscopy of pure drug, niosome, and niosome with drugs were taken. When the cholesterol was increased from 30% micromole to 50% micromole, niosome average size was increased. The molar ratio 70: 30 of span and cholesterol was more appropriate for the preparation of niosome drug delivery. By adding distill phosphate and acetyl Tri-methyl ammonium bromide to niosomeal compounds, the average vesicle size and the loading percentage were increased.