Abstract
Calcium phosphate is a main inorganic constituent of bone, which can be interpreted as a composite material of calcium phosphate and collagen. This calcium phosphate shows a similar chemical composition with hydroxyapatite (HAP). Many devices with HAP have been developed for medical use because of its excellent biocompatibility. The hardness of HAP is adequate to supportive and protective functions in the skeleton and it also plays an important roll as homeostatic regulator of Ca and PO4 in the blood and other body fluids. The regulation process is closely connected to the remodeling of bone. Bone is renewed and reconstructed throughout the lifetime of the individual and therefore, HAP as biomaterial should be compatible to this dynamic remodeling process. We developed a new technology to control the pore size in HAP. The size of pore was controlled by applying HAP powder of nm-size and nylon- and acryl-monofilaments. The HAP processed with nylon-monofilament (f=80μm) showed the similar micro-pores to those of the Haversian canal in the natural bone. This porous HAP can be applied to a biofilter and a drug-delivery system.
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