Abstract
Asymmetric synthesis from achiral starting materials using only crystal chirality under absolutely achiral conditions-that is, absolute asymmetric synthesis-has been investigated by many methods, including solid-state photochemical reactions, asymmetric reactions using frozen chirality, and dynamic crystallization (total spontaneous resolution). Dynamic crystallization using racemic conglomerate crystals involved that an enantiomerically enriched solid state could be achieved through crystallization from a solution in which chiral molecules could rapidly racemize. Many such examples resulted in total optical resolution by deracemization, selectively leading to single-handed molecules. Furthermore, a combined methodology for generating a chiral center from achiral materials, involving dynamic crystallization or attrition-enhanced deracemization, was recently developed. These examples demonstrate the high potential of this new category of absolute asymmetric synthesis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.