Abstract
All vertebrate cells, including muscle cells, contain nonmuscle myosin II which plays a role in a number of cell motility processes. Dynamic filament assembly-disassembly transition of myosin II molecules is particularly important in nonmuscle cells. In this review, we describe our recently proposed molecular mechanism for the filament formation of nonmuscle myosin II. We also discuss the distinct functions of two myosin II isoforms, IIA and IIB, during cell migration.
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