Abstract
We have reported that the renal vasotoxic substance is included in the microsomal fraction of renal cortical extracts, and that the fraction has no-pressor effect.In this experiment, Ouchterlony method and immuno-electrophoretic analysis are used in order to identify the renal vasotoxic substance in serum immunologically. Antigen-antibody reactions are performed using the rat serum which is treated with transient renal ischemia, and using anti-rat renal microsomal fraction rabbit serum. Ouchterlony method points out specific antigen antibody reaction lines clearly. Immuno-electrophoretic analysis also points out five bands corresponding with α1, α2, β, γ-globulin levels.This results suggest a possibility that the injured kidney releases the renal vasotoxic substance which results in various vascular lesions.
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