上顎洞癌患者の経過観察中に生じた薬剤起因性大腸炎の１症例

Abstract

This paper described a case of drug induced colitis with maxillary sinus cancer in the follow-up period.A 45-year-old male with left maxillary sinus cancer (T4N0M0) was treated by surgical interventions (extirpation of metastatic lymph nodes; radical neck dissection), cryotherapy, radiation therapy with and without 5-FU administration from superficial temporal artery, hyperthermia, and chemotherapy (Cisplatin, Peplomycin and Vincristine). Furthermore, oral administration of UFT and intradermal injection of OK-432 were also carried out.He complained of fever and severe diarrhea in the follow-up period after the above treatments and was diagnosed as drug-induced colitis. OK-432 was suspected to be a causative of the drug induced colitis by lymphocyte stimulation test (LST) and tar stool appeared after accidental readministration of the ctrug.