Abstract
Objective: To explore the clinical efficacy and side effects of buspirone treatment combined with music intervention on generalized anxiety disorder (GAD). Method: 80 enrolled GAD patients were randomly divided into intervention group (buspirone treatment combined with music intervention) and the control group (buspirone treatment only), each group had 40 patients. HAMA (Hamilton Rating Scale for Anxiety) and TESS (Treatment Emergent Symptom Scale) were assessed in the baseline and 1 week, 3 weeks and 6 weeks after each treatment to evaluate the efficacy and side effects. Results: The combined patients were scored significantly less in total HAMA score, the somatic anxiety factor and the psychic anxiety factor after 6-week treatment compared with the control patients (separately 9.63±3.78 vs 12.65±3.76，0.52±0.39 vs 0.69±2.89，0.85±0.28 vs 1.12±0.34, t ＝－3.59、－2.20、－3.81, P ＜0.01, P ＜0.05, P ＜0.01). Conclusion: Music intervention could reduce anxious symptoms largely, the clinical efficacy buspirone treatment combined with music intervention is better than the single use of buspirone when GAD patients are treated.
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