Abstract
Cis-diamine-dichloro-platinum (Cisplatin, CDDP) is known as a common carcinostatic drug. On the other hand, it has harmful side effects, such as ototoxicity, renal toxicity and bone marrow depression.Audiometric analyses w ere performed in 21 patients treated with CDDP from 1986 to 1990. Pure tone threshold shift of more than 20 dB at least one frequency was recognized in 8 out of 21 patients. After CDDP treatment,1 patient demonstrated total deafness, and 7patients demonstrated a significant hearing loss at 8 kHz. All of the 5 patients complained of tinnitus revealed a significant hearing loss. A hearing disorder was recognized in all patients treated with CDDP at a single dose of more than 150 mg, but no patient showed any hearing disorder among the patients treated with a single dose of less than 100 mg. These findings suggested that hearing disorders induced by CDDP occur in the relation to a single dose of CDDP rather than a total dose.
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