Abstract
The magnetic enzyme sensor (MES) is a thermal biosensor utilizing temperature-sensitive ferrimagnetic thin film with a composition of MnxZn1-xFe2O4, prepared by sputtering and annealing processes. Temperature-sensitive ferrimagnetic thin film with a marked temperature dependence has the ability to detect temperature variations of as little as 10-3°C, so application of the film to an enzyme sensor is possible. The conventional enzyme sensor is an electronic device using a semiconductor, such as a thermistor, whereas MES is a magnetic detector utilizing temperature dependence of the temperature-sensitive ferrimagnetic thin film. The temperature rise due to an enzyme reaction is less than 10-2°C, and it is difficult to detect with a conventional magnetic sensor because of the large heat of the capacitor and the instability of the magnetic signal readout. The MES is, accordingly, proposed for detecting chemical substances and the metabolites due to enzyme reactions. The MES can be used in the fields of biochemistry and biomagnetics for clinical chemical analysis, process measurement, and hygiene management of foods. This paper describes construction of the MES, and a logic circuit expression for response characteristics.
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