骨粗しょう症の進行に関する理論的解析

Abstract

Osteoporosis is a disease caused by an abnormal bone metabolism. In this paper, it was attempted to explain the progressive rate of osteoporosis based on the product of bone remodeling activity and morphological parameters of the trabecular structure of the cancellous bone. The main results obtained were as follows.As the bone formation became slow, the bone volume gradually decreased and the cortical bone was thinned. Furthermore, the porosity of the cancellous bone increased abnormally. These changes greatly impaired the mechanical properties of the bones. These abnormalities may also cause such a bone fracture as intracapsular femoral neck fracture.The value Vf obtained by the equation (13) is considered to represent the progressing behavior of osteoporosis at the proximal end of the femur.From the measurment of the metabolic activity and quantification of the morphological properties of cancellous bone structure, it was concluded that the highest progressive rate of resorption appeared in bar/bar like trabecular structure. The plate/bar like structure was the next and the plate/plate like structure was most insensitive.